Resveratrol is a popular supplement in the anti-aging world, due to its anti-oxidant-like properties. It’s part of a group of compounds called polyphenols that protect the body against damage – found mainly in the skin of red grapes, but also in red wine, berries and peanuts.
Anti-oxidants are always on the radar for preserving egg and sperm quality, which are very vulnerable to oxidative damage during their 3-month maturation process. A new joint US-India systematic review has studied the effects of resveratrol on male fertility and sperm preservation. It found the strongest evidence in in-vitro studies where resveratrol was used to protect spermatozoa against damage due to freeze-thaw cycles during cryopreservation (when a sperm sample is frozen until future use). Evidence was also found in in-vitro studies for fresh samples and protection of cell lines.
To date I have been prescribing resveratrol to my female fertility patients (at a dosage of 200mg trans-resveratrol per day) – I’m excited to potentially bring this into male fertility treatment plans as well!
I hope you have found this helpful, and do let me know if you have any questions!
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In health,
Dr Jocelyn Land-Murphy, ND
Terra Life
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References:
Cannarella, R. et al. (2024). Resveratrol and male infertility: a systematic review of the literature. Minerva Endocrinol.